Deputy Derrick Stuckey of Huntsville Fire and Rescue says one person was found dead inside the home.
He said it it not yet known if the person died before or during the fire.
Huntsville police say the victim is a male, and the fire is being investigated as arson. Police said this is standard protocol because there is a death.
The fire began about 6:13 a.m. and firefighters found the house fully involved.
Firefighters are working on putting out hotspots now.
The area will be blocked off for awhile.
Huntsville Fire and Rescue are on the scene of a house fire in south Huntsville.
Crews responded to the scene in the 13000 block of Wyandotte Drive around 6:20 a.m. Thursday morning.
WAAY 31 has a crew on the scene and will update this story with the latest information.