Huntsville Fire & Rescue crews responded to Bishop's Eastside Pub & Grill on Winchester road Friday morning.
The pub has extensive damage to the building, according to Capt. Frank McKenzie, Huntsville Fire & Rescue spokesman. He said investigators are working to determine how the fire started. It's believed it started in the back of the building.
McKenzie said no one was inside when the fire happened, and it was closed on Thanksgiving.
Utitlity crews cut off the electricity to the pub and Jade Nail Spa next door, according to McKenzie. He said none of the other businesses have fire damage.
Firefighters on scene said it took about 45 minutes to get the fire under control.
As of 11 o'clock Friday morning, fire investigators are still at the pub working to determine the cause of the fire.
It's unknown when the business will reopen.