Kaléo to offer lower-priced opioid antidote

Pharmaceutical company Kaléo ...

Posted: Dec 12, 2018 3:48 PM
Updated: Dec 12, 2018 3:48 PM

Pharmaceutical company Kaléo announced Wednesday that it will offer a generic version of its opioid antidote Evzio for $178 for a carton containing two single-dose auto-injector pens.

Evzio was approved by the US Food and Drug Administration in April 2014 under an expedited review for "the emergency treatment of known or suspected opioid overdose, characterized by decreased breathing or heart rates, or loss of consciousness." In these instances, it can quickly reverse the effects of opioids.

Business and industry sectors

Business, economy and trade

Companies

Controlled substances

Drug overdoses

Drug prices

Drugs and society

Health and medical

Health care

Health care costs

Investigations

Kaleo Pharma

Opioids

Pharmaceutical industry

Pharmaceuticals

Pharmaceuticals and prescription drugs

Society

Substance abuse

The active ingredient, naloxone, comes in an auto-injector pen that is administered into a muscle and easy to use by bystanders or family members who are not medically trained. Evzio is different from other naloxone products because it gives verbal instructions to the user.

The price for the life-saving drug was initially set at $575 in July 2014, but was increased as high as $4,100 in January 2017, a US Senate subcommittee investigation found last month.

The investigation by the Permanent Subcommittee on Investigations, which is under the Committee on Homeland Security and Governmental Affairs, uncovered how Kaléo "exploited the opioid crisis by increasing the price of its naloxone drug Evzio by more than 600 percent by 2016," according to Chairman Rob Portman, a Republican of Ohio.

The subcommittee's report said the higher cost was a result of a new distribution model to "capitalize on the opportunity of opioid overdoses at epidemic levels."

"This news is a positive step forward and I'm hopeful that it will increase access to naloxone, a critically-important overdose reversal drug that has saved tens of thousands of lives," Portman said of Wednesday's announcement.

The company said the new generic will be available through its subsidiary, IJ Therapeutics, in mid-2019.

In the meantime, the same $178 price is available immediately for government agencies, first responders and other health care providers through a new public access pricing program.

According to Kaléo, some patients with commercial health insurance plans already qualify to get Evzio at no out-of-pocket cost.

"The lower list price of the authorized generic will offer a more affordable and cost-effective solution for Medicare Part D patients and plans," the company said.

The subcommittee investigation found that the price increases by Kaléo cost taxpayers more than $142 million as of November 18, "just in the last four years, despite the fact that less costly versions of naloxone exist."

Delaware Sen. Tom Carper, a Democrat who led the Senate investigation with Portman, said this is a step in the right direction. "Life-saving drugs should not be out of reach for those that need them most, especially in the midst of a deadly public health crisis."

Huntsville/Redstone
Partly Cloudy
71° wxIcon
Hi: 74° Lo: 47°
Feels Like: 71°
Muscle Shoals
Partly Cloudy
73° wxIcon
Hi: 74° Lo: 43°
Feels Like: 73°
Huntsville/Madison
Partly Cloudy
71° wxIcon
Hi: 72° Lo: 43°
Feels Like: 71°
Decatur
Partly Cloudy
72° wxIcon
Hi: 75° Lo: 45°
Feels Like: 72°
Fort Payne
Partly Cloudy
70° wxIcon
Hi: 73° Lo: 44°
Feels Like: 70°
WAAY Radar
WAAY WAAY-TV Cam
WAAY Temperatures

Alabama Coronavirus Cases

Cases: 522512

Reported Deaths: 10790
CountyCasesDeaths
Jefferson755371494
Mobile39129799
Madison34124500
Tuscaloosa25408444
Montgomery24059573
Shelby23225242
Baldwin20730302
Lee15638166
Calhoun14358311
Morgan14171273
Etowah13705348
Marshall12012220
Houston10416279
Elmore10024203
Limestone9862148
Cullman9509191
St. Clair9486236
Lauderdale9280233
DeKalb8762183
Talladega8127173
Walker7151276
Autauga6763106
Jackson6762110
Blount6532133
Colbert6236132
Coffee5436113
Dale4781111
Russell431239
Franklin421382
Chilton4130110
Covington4069115
Tallapoosa3922148
Escambia390374
Dallas3528150
Chambers3519122
Clarke347360
Marion3076100
Pike306676
Lawrence296395
Winston273272
Bibb256761
Marengo248561
Geneva246475
Pickens233259
Barbour227155
Hale218675
Butler213268
Fayette209660
Henry188444
Cherokee182744
Randolph177841
Monroe173140
Washington165538
Macon156548
Clay150255
Crenshaw149557
Cleburne147041
Lamar140034
Lowndes137353
Wilcox124727
Bullock122040
Conecuh109728
Perry107726
Sumter103332
Coosa99428
Greene91434
Choctaw58824
Out of AL00
Unassigned00

Tennessee Coronavirus Cases

Cases: 835842

Reported Deaths: 12081
CountyCasesDeaths
Shelby930851587
Davidson88030924
Knox49813624
Hamilton43402485
Rutherford42319420
Williamson27545216
Sumner23492341
Montgomery19623224
Wilson18472229
Out of TN1803295
Unassigned16760132
Sullivan16184287
Blount15180194
Bradley14599147
Washington14177242
Maury13211169
Sevier13166175
Putnam11168173
Madison10789241
Robertson9607130
Anderson8627171
Hamblen8498171
Greene7739152
Tipton7226104
Coffee6831121
Dickson6734109
Cumberland6568127
Carter6468156
Bedford6426129
Gibson6402144
McMinn636597
Roane6191102
Jefferson6073121
Loudon601669
Lawrence580686
Hawkins5781106
Monroe570995
Warren551381
Dyer5361104
Franklin508688
Fayette492178
Obion450296
Cheatham444454
Cocke443798
Rhea431275
Lincoln430663
Marshall411158
Campbell409662
Weakley402862
Giles395399
Henderson372975
Macon358077
Carroll357582
White354868
Hardin349766
Hardeman346464
Lauderdale314444
Henry312475
Marion309946
Claiborne306273
Scott305545
Overton296961
Wayne294334
Hickman280546
McNairy276854
DeKalb275653
Smith274838
Haywood268361
Grainger259149
Trousdale249022
Morgan246039
Fentress238546
Johnson231638
Bledsoe209711
Chester209451
Crockett201048
Polk200024
Unicoi194549
Cannon188931
Union186034
Grundy177933
Humphreys174221
Lake169526
Sequatchie166728
Benton163240
Decatur157338
Lewis155826
Meigs134823
Stewart130828
Jackson129935
Clay109031
Houston108533
Perry105728
Moore100017
Van Buren83421
Pickett75624
Hancock54912

Community Events